SMAD7 antibody
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Description
Antagonist of signaling by TGF-beta(transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta(Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator(By similarity).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | SMAD family member 7 (SMAD7) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 46 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | O15105 |
| Gene ID | 4092 |
| Alias | Mothers against decapentaplegic homolog 7 (MAD homolog 7, Mothers against DPP homolog 7),Mothers against decapentaplegic homolog 8 (MAD homolog 8, Mothers against DPP homolog 8),SMAD family member 7 (SMAD 7, Smad7, hSMAD7),SMAD7,MADH7,MADH8 |
| Background | Antibody anti-SMAD7 |
| Status | RUO |
| Note | Mol. Weight 46 kDa |
Descripción
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