NUP205 antibody
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935106861
info@markelab.com
name
NUP205 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab05923
tested applications
ELISA, WB, IHC
Description
Plays a role in the nuclear pore complex(NPC) assembly and/or maintenance. May anchor NUP62 and other nucleoporins, but not NUP153 and TPR, to the NPC.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | nucleoporin 205kDa (NUP205) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 205 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q92621 |
| Gene ID | 23165 |
| Alias | NPHS13,C7orf14, Nuclear pore complex protein Nup205,205 kDa nucleoporin,chromosome 7 open reading frame 14 |
| Background | Antibody anti-NUP205 |
| Status | RUO |
| Note | Mol. Weight 205 kDa |
Descripción
Nucleoporin 205 (NUP205) is a key structural component of the nuclear pore complex, contributing to the formation of the nuclear pore's central channel NUP205 works with other nucleoporins to regulate the transport of large macromolecules, such as RNA and proteins, between the nucleus and the cytoplasm It plays an important role in maintaining the selectivity and efficiency of molecular exchange, essential for processes like gene expression, cell signaling, and cellular stress responses NUP205 is involved in regulating the movement of critical proteins, such as transcription factors and cell cycle regulators, that are essential for maintaining normal cellular function Dysregulation of NUP205 is linked to several diseases, including cancers, where impaired nucleocytoplasmic transport contributes to abnormal gene expression and tumor progression Additionally, NUP205’s function in maintaining the stability and structure of the nuclear pore is critical for nuclear envelope integrity during cell division
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