Nuclear receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism(By similarity). Exhibits a ligand-dependent transcriptional activation activity(PubMed:25661920).
Primary Antibodies
monoclonal
human,rat
nuclear receptor subfamily 1, group H, member 3
Mouse
IgG2a
Unconjugated
liquid
ELISA, WB, IF
48 kDa
≥95% as determined by SDS-PAGE
Protein A+G purification
WB: 1:200-1:1000; IF: 1:10-1:100
100µg
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
NR1H3
LXRA,LXR-a,RLD-1,Oxysterols receptor LXR-alpha,Liver X receptor alpha,Nuclear receptor subfamily 1 group H member 3
This product is for research use only.
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