MME antibody
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935106861
info@markelab.com
name
MME antibody
category
Primary Antibodies
provider
FineTest
reference
FNab05232
tested applications
ELISA, IHC, WB
Description
MME is also names as neprilysin,CALLA,NEP,SFE,CD10 and belongs to the peptidase M13 family.It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium.CD10 has been considered a useful marker in the diagnosis of renal carcinomas, because of its expression in clear cell and papillary renal cell carcinomas and its absence in chromophobe renal cell carcinomas(PMID:15286660).This antibody is specific to MME.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | membrane metallo-endopeptidase (MME) |
| Host | Mouse |
| Reactivity | Human, Pig |
| Recommended Dilution | WB: 1:500-1:5000; IHC: 1:20-1:200 |
| Clonality | monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2a |
| Clone ID | 1H6 |
| Observed MW | 90-110 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Protein A+G purification |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P08473 |
| Gene ID | 4311 |
| Alias | NEP,SFE,CD10; CALLA,CMT2T,SCA43,Atriopeptidase,Enkephalinase,Neutral endopeptidase,Skin fibroblast elastase |
| Background | Antibody anti-MME |
| Status | RUO |
| Note | Mol. Weight 90-110 kDa |
Descripción
MME, also known as neprilysin (NEP) or CD10, is a zinc-dependent metalloprotease enzyme that plays a critical role in various physiological processes, particularly through the degradation of small peptides. Neprilysin is most commonly found on the cell surfaces of various tissues, including the kidneys, lungs, intestines, and the central nervous system. Its primary function involves regulating the levels of biologically active peptides by catalyzing their breakdown, thus influencing many biological systems, including cardiovascular and renal function, pain sensation, and immune responses. Neprilysin is particularly significant in the context of cardiovascular diseases, especially in the metabolism of natriuretic peptides such as atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP), both of which play crucial roles in regulating blood pressure and fluid balance. It also degrades neuropeptides like substance P and bradykinin, as well as amyloid-beta peptides in the brain, thus connecting neprilysin to pathologies such as hypertension, heart failure, and Alzheimer's disease.
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