CSTF1 antibody
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935106861
info@markelab.com
name
CSTF1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab02037
tested applications
ELISA, WB, IP
Description
One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa (CSTF1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IP: 1:200-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 50 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IP |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q05048 |
| Gene ID | 1477 |
| Alias | CstF-50,CstFp50,CF-1 50 kDa subunit,Cleavage stimulation factor 50 kDa subunit |
| Background | Antibody anti-CSTF1 |
| Status | RUO |
| Note | Mol. Weight 50 kDa |
Descripción
Cleavage stimulation factor subunit 1 (CSTF1) is a component of the cleavage stimulation factor (CstF) complex, which is crucial for the polyadenylation and 3' end cleavage of pre-mRNAs. CSTF1 contains transducin-like WD40 repeats and functions as a homodimer within the CstF complex. It interacts directly with CSTF2 and CSTF3 to form the heterotrimeric CstF complex, which assembles on the pre-mRNA to facilitate cleavage and subsequent polyadenylation. CSTF1 is responsible for mediating interactions between CstF and other factors, ensuring the formation of a stable complex on the pre-mRNA. The expression levels of CstF components, including CSTF1, vary during the cell cycle, increasing significantly during the transition from G0 to S phase, indicating a role in cell cycle-regulated mRNA processing. Additionally, CSTF1 has been shown to interact with BARD1, linking mRNA 3' end formation to DNA damage response and tumor suppression pathways.
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