BUB1 antibody
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Description
This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of cancer. Alternate splicing results in multiple transcript variants.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | budding uninhibited by benzimidazoles 1 homolog (yeast) (BUB1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500 - 1:2000; IHC: 1:50 - 1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 133 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| UniProt ID | O43683 |
| Gene ID | 699 |
| Alias | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1),BUB1A,BUB1,BUB1L |
| Background | Antibody anti-BUB1 |
| Status | RUO |
| Note | Mol. Weight 133 kDa |
Descripción
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