ALDOA antibody
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Name
ALDOA antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab00301
Tested Applications
ELISA, WB, IHC, IF, IP, FC
Description
Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein(By similarity).
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | aldolase A, fructose-bisphosphate (ALDOA) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:5000; IHC: 1:20-1:200; IF: 1:10-1:100 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 39 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IF, IP, FC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P04075 |
| Gene ID | 226 |
| Alias | ALDOA,ALDA |
| Background | Antibody anti-ALDOA |
| Status | RUO |
| Note | Mol. Weight 39 kDa |
Background
ALDOA is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate into glyceraldehyde-3-phosphate and dihydroxyacetone phosphate during glycolysis. It is widely expressed, particularly in muscle tissues and the brain, where it plays a crucial role in energy metabolism and ATP production. ALDOA is vital for providing energy to rapidly proliferating cells and tissues with high metabolic demands. Dysregulation of ALDOA has been associated with cancer progression, as elevated glycolytic activity (Warburg effect) fuels tumor growth. Mutations in ALDOA cause glycogen storage disease type XII, characterized by hemolytic anemia and muscle weakness due to impaired glycolytic flux. Its role in energy metabolism underscores its importance in cellular homeostasis, growth, and disease.
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