ALDH1L1 antibody
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935106861
info@markelab.com
name
ALDH1L1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00289
tested applications
ELISA, WB, IHC
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | aldehyde dehydrogenase 1 family, member L1 (ALDH1L1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:200-1:1000; IHC: 1:20-1:200; IP: 1:200-1:2000; IF: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 99 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | O75891 |
| Gene ID | 10840 |
| Alias | ALDH1L1,FTHFD |
| Background | Antibody anti-ALDH1L1 |
| Status | RUO |
| Note | Mol. Weight 99 kDa |
ALDH1L1, also known as 10-formyltetrahydrofolate dehydrogenase, is a cytosolic enzyme involved in folate metabolism, where it catalyzes the conversion of 10-formyltetrahydrofolate to tetrahydrofolate, a key process in one-carbon metabolism. This enzyme plays a significant role in nucleotide biosynthesis, DNA methylation, and cellular proliferation by regulating the folate cycle and one-carbon pools. ALDH1L1 is highly expressed in the liver and brain, where it supports metabolic processes and detoxification. It functions as a tumor suppressor, as its loss or downregulation is associated with various cancers, including liver, breast, and lung cancers, due to impaired folate metabolism and increased cellular proliferation. ALDH1L1 also contributes to cellular detoxification by reducing reactive aldehydes and maintaining redox balance. Emerging studies highlight its potential as a biomarker for cancer prognosis and as a therapeutic target for restoring normal folate metabolism in tumor cells.
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