Aldehyde Dehydrogenase 1 Family Member L1 (ALDH1L1) Antibody
195€ (20 µl)
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Name
Aldehyde Dehydrogenase 1 Family Member L1 (ALDH1L1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx006886
Tested Applications
ELISA, WB
Description
ALDH1L1 Antibody is a Rabbit Polyclonal Antibody against ALDH1L1.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Aldehyde Dehydrogenase 1 Family Member L1 (ALDH1L1) Immunogen: Recombinant protein corresponding to ALDH1L1. The exact sequence is proprietary. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: > 0.2 mg/ml |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 99 kDa Observed MW: 120 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O75891 |
| Gene ID | 10840 |
| NCBI Accession | NP_036322.2 |
| Alias | ALDH1L1,FTHFD |
| Background | Antibody anti-ALDH1L1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ALDH1L1, also known as 10-formyltetrahydrofolate dehydrogenase, is a cytosolic enzyme involved in folate metabolism, where it catalyzes the conversion of 10-formyltetrahydrofolate to tetrahydrofolate, a key process in one-carbon metabolism. This enzyme plays a significant role in nucleotide biosynthesis, DNA methylation, and cellular proliferation by regulating the folate cycle and one-carbon pools. ALDH1L1 is highly expressed in the liver and brain, where it supports metabolic processes and detoxification. It functions as a tumor suppressor, as its loss or downregulation is associated with various cancers, including liver, breast, and lung cancers, due to impaired folate metabolism and increased cellular proliferation. ALDH1L1 also contributes to cellular detoxification by reducing reactive aldehydes and maintaining redox balance. Emerging studies highlight its potential as a biomarker for cancer prognosis and as a therapeutic target for restoring normal folate metabolism in tumor cells.
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