Aldehyde Dehydrogenase 1 Family Member L1 (ALDH1L1) Antibody
292.5€ (80 µl)
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935106861
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name
Aldehyde Dehydrogenase 1 Family Member L1 (ALDH1L1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx033714
tested applications
ELISA, WB, IHC
Description
ALDH1L1 catalyzes the conversion of 10-formyltetrahydrofolate, NADP, and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family and is responsible for formate oxidation in vivo. Deficiencies in this gene can result in an accumulation of formate and subsequent methanol poisoning.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Aldehyde Dehydrogenase 1 Family Member L1 (ALDH1L1) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O75891 |
| NCBI Accession | NP_001257293.1, NP_001257294.1, NP_036322.2 |
| Alias | ALDH1L1,FTHFD |
| Background | Antibody anti-ALDH1L1 |
| Status | RUO |
Descripción
ALDH1L1, also known as 10-formyltetrahydrofolate dehydrogenase, is a cytosolic enzyme involved in folate metabolism, where it catalyzes the conversion of 10-formyltetrahydrofolate to tetrahydrofolate, a key process in one-carbon metabolism. This enzyme plays a significant role in nucleotide biosynthesis, DNA methylation, and cellular proliferation by regulating the folate cycle and one-carbon pools. ALDH1L1 is highly expressed in the liver and brain, where it supports metabolic processes and detoxification. It functions as a tumor suppressor, as its loss or downregulation is associated with various cancers, including liver, breast, and lung cancers, due to impaired folate metabolism and increased cellular proliferation. ALDH1L1 also contributes to cellular detoxification by reducing reactive aldehydes and maintaining redox balance. Emerging studies highlight its potential as a biomarker for cancer prognosis and as a therapeutic target for restoring normal folate metabolism in tumor cells.
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