Aldehyde Dehydrogenase 1 Family Member L1 (ALDH1L1) Antibody

Product specifications

Primary Antibodies

Aldehyde Dehydrogenase 1 Family Member L1 (ALDH1L1)

Rabbit

Human, Mouse, Rat

WB: 1/200 - 1/1000, IHC: 1/20 - 1/200, IP: 1/200 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

Unconjugated

IgG

≥ 95% (SDS-PAGE)

Purified by immunogen affinity chromatography.

100 µg

Liquid

ELISA, WB, IHC

PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.

Shipped within 5-12 working days.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

O75891

10840

600249

ALDH1L1,FTHFD

Antibody anti-ALDH1L1

RUO

Concentration: 2 mg/ml - Validity: 12 months.

Descripción

ALDH1L1, also known as 10-formyltetrahydrofolate dehydrogenase, is a cytosolic enzyme involved in folate metabolism, where it catalyzes the conversion of 10-formyltetrahydrofolate to tetrahydrofolate, a key process in one-carbon metabolism. This enzyme plays a significant role in nucleotide biosynthesis, DNA methylation, and cellular proliferation by regulating the folate cycle and one-carbon pools. ALDH1L1 is highly expressed in the liver and brain, where it supports metabolic processes and detoxification. It functions as a tumor suppressor, as its loss or downregulation is associated with various cancers, including liver, breast, and lung cancers, due to impaired folate metabolism and increased cellular proliferation. ALDH1L1 also contributes to cellular detoxification by reducing reactive aldehydes and maintaining redox balance. Emerging studies highlight its potential as a biomarker for cancer prognosis and as a therapeutic target for restoring normal folate metabolism in tumor cells.

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