AKAP1 antibody
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935106861
info@markelab.com
name
AKAP1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00249
tested applications
ELISA, WB, IF, IHC, FC, IP
Description
Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | A kinase(PRKA) anchor protein 1 (AKAP1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:500-1:5000; IHC: 1:20-200; IP: 1:1000-10000; IF: 1:10-100 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 149 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IF, IHC, FC, IP |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q92667 |
| Gene ID | 8165 |
| Alias | AKAP,AKAP121,AKAP149,AKAP84,D-AKAP1 |
| Background | Antibody anti-AKAP1 |
| Status | RUO |
| Note | Mol. Weight 149 kDa |
Descripción
AKAP1 is a mitochondrial scaffold protein that anchors Protein Kinase A (PKA) and other signaling molecules to the outer mitochondrial membrane, regulating mitochondrial dynamics, energy production, and apoptosis. AKAP1 modulates mitochondrial membrane potential by organizing signaling complexes involving PKA, phosphatases, and other enzymes. It plays a significant role in cardiomyocyte survival, as it enhances mitochondrial respiration under stress by promoting ATP synthesis. AKAP1 is also involved in the regulation of mitochondrial fission and fusion through interactions with Drp1 and MFN2, thereby maintaining mitochondrial homeostasis. Loss of AKAP1 disrupts mitochondrial function and increases susceptibility to oxidative stress, contributing to neurodegeneration and heart failure. AKAP1 also regulates reactive oxygen species (ROS) production, influencing cellular aging and survival signaling pathways like AMPK. Recent studies have linked AKAP1 downregulation with metabolic disorders and impaired endothelial function, highlighting its role in vascular biology.
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