AGR2 antibody
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Name
AGR2 antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab00219
Tested Applications
ELISA, WB, IHC, IP, FC
Description
Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells(By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth.
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | anterior gradient homolog 2 (AGR2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:1000-1:5000; IHC: 1:20-1:500; IP: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 17-20 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IP, FC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | O95994 |
| Gene ID | 10551 |
| Alias | AG-2,AG2,GOB-4,HAG-2,HEL-S-116,HPC8 |
| Background | Antibody anti-AGR2 |
| Status | RUO |
| Note | Mol. Weight 17-20 kDa |
Background
AGR2 is a protein involved in the endoplasmic reticulum (ER) stress response and functions as a protein disulfide isomerase (PDI), facilitating the proper folding of secreted and membrane proteins. It is primarily expressed in secretory tissues such as the gastrointestinal tract, lungs, and prostate, where it maintains ER homeostasis by catalyzing the formation of disulfide bonds in proteins. AGR2 also plays a role in cell adhesion and migration, partly through its interaction with mucins like MUC1 and MUC2. Overexpression of AGR2 is frequently observed in cancers, including breast, pancreatic, and prostate cancers, where it contributes to tumor progression, chemoresistance, and metastasis by promoting cell survival under stress conditions
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