GTPase-activating protein(GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1(GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1(AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.
Primary Antibodies
polyclonal
human,mouse,rat
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Rabbit
IgG
Unconjugated
liquid
ELISA, WB, IHC, IF
125 kDa
≥95% as determined by SDS-PAGE
Immunogen affinity purified
WB: 1:500-1:5000; IP: 1:200-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
100µg
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
AGAP2
CENTG1,GGAP2,PIKE
This product is for research use only.
GTPase-activating protein(GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the...
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