anti- AGAP2 antibody

Name: anti- AGAP2 antibody
Brand: FineTest
SKU: FNab00205
Availability: OnlineOnly

Este producto es parte de AGAP - Arf-GAP with GTPase ANK repeat and PH domain-containing protein

Pida mas información

935106861

info@markelab.com

Precio

Precio a consultar

Antibody anti-AGAP2

proveedor

FineTest

reference

FNab00205

Tested Applications

ELISA, WB, IHC, IF

reactivity

human,mouse,rat

status

RUO

clonality

polyclonal

Descripción

GTPase-activating protein(GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1(GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1(AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.

Background

AGAP2, also known as PIKE-A, plays a key role in regulating cell survival, growth signaling pathways, and intracellular transport. It interacts with phosphoinositide 3-kinase (PI3K), enhancing PI3K-Akt signaling and promoting anti-apoptotic responses. AGAP2 contains a GTPase domain, ankyrin repeats, and a PH domain, enabling its participation in vesicle trafficking, cytoskeletal dynamics, and endosomal transport. It is expressed in neurons, where it supports synaptic stability and neuronal survival, and is overexpressed in cancers such as glioblastomas, driving tumor growth and resistance to apoptosis. AGAP2’s dual roles in neuronal plasticity and oncogenesis make it a significant target for therapeutic research.

Características del producto

clonality

polyclonal

reactivity

human,mouse,rat

immunogen target

ArfGAP with GTPase domain, ankyrin repeat and PH domain 2

host

Rabbit

isotype

IgG

conjugation

Unconjugated

form

liquid

tested applications

ELISA, WB, IHC, IF

observerd MW

125 kDa

purity

≥95% as determined by SDS-PAGE

purification

Immunogen affinity purified

recommended dilution

WB: 1:500-1:5000; IP: 1:200-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200

size 1

100µg

storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

or code

AGAP2

alias

CENTG1,GGAP2,PIKE

uniprot id

https://www.uniprot.org/uniprotkb/Q99490

gene id

https://www.ncbi.nlm.nih.gov/gene/116986

note

This product is for research use only.

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