Arf-GAP With GTPase, ANK Repeat And PH Domain Containing Protein 2 (AGAP2) Antibody
357.5€ (100 µg)
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Name
Arf-GAP With GTPase, ANK Repeat And PH Domain Containing Protein 2 (AGAP2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx038317
Tested Applications
ELISA, WB, IHC
Description
Rabbit Polyclonal against the AGAP2 protein.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Arf-GAP With GTPase, ANK Repeat And PH Domain Containing Protein 2 (AGAP2) Immunogen: A peptide corresponding to C-terminal region of human AGAP2 protein. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 125 kDa |
| Purification | Purified by Protein A/G column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NM_001122772.1 |
| Alias | CENTG1,GGAP2,PIKE |
| Background | Antibody anti-AGAP2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
AGAP2, also known as PIKE-A, plays a key role in regulating cell survival, growth signaling pathways, and intracellular transport. It interacts with phosphoinositide 3-kinase (PI3K), enhancing PI3K-Akt signaling and promoting anti-apoptotic responses. AGAP2 contains a GTPase domain, ankyrin repeats, and a PH domain, enabling its participation in vesicle trafficking, cytoskeletal dynamics, and endosomal transport. It is expressed in neurons, where it supports synaptic stability and neuronal survival, and is overexpressed in cancers such as glioblastomas, driving tumor growth and resistance to apoptosis. AGAP2’s dual roles in neuronal plasticity and oncogenesis make it a significant target for therapeutic research.
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