Arf-GAP With GTPase, ANK Repeat And PH Domain Containing Protein 2 (AGAP2) Antibody

Background

AGAP2, also known as PIKE-A, plays a key role in regulating cell survival, growth signaling pathways, and intracellular transport. It interacts with phosphoinositide 3-kinase (PI3K), enhancing PI3K-Akt signaling and promoting anti-apoptotic responses. AGAP2 contains a GTPase domain, ankyrin repeats, and a PH domain, enabling its participation in vesicle trafficking, cytoskeletal dynamics, and endosomal transport. It is expressed in neurons, where it supports synaptic stability and neuronal survival, and is overexpressed in cancers such as glioblastomas, driving tumor growth and resistance to apoptosis. AGAP2’s dual roles in neuronal plasticity and oncogenesis make it a significant target for therapeutic research.