anti- ADCY1 antibody
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935106861
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name
anti- ADCY1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00155
tested applications
ELISA, WB
Description
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca(2+)/calmodulin levels(By similarity). May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina(By similarity).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | adenylate cyclase 1(brain) |
| Host | Rabbit |
| Reactivity | human |
| Recommended Dilution | WB: 1:200-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 123 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q08828 |
| Gene ID | 107 |
| Alias | AC1,DFNB44,ATP pyrophosphate-lyase 1 |
| Background | Antibody anti-ADCY1 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
ADCY1 is a membrane-bound enzyme predominantly expressed in the brain, specifically in neuronal tissues. It is activated by G-protein-coupled receptors (GPCRs) and regulated by calcium/calmodulin, playing a vital role in generating cyclic AMP (cAMP), a second messenger critical for signal transduction. ADCY1 is essential for synaptic plasticity, learning, and memory processes. Dysregulation of ADCY1 has been linked to neurological disorders, such as cognitive impairments and epilepsy, due to impaired cAMP signaling pathways. Its expression and activity are crucial for calcium-dependent cAMP production in neurons.
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