anti- ACSS1 antibody
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935106861
info@markelab.com
name
anti- ACSS1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00113
tested applications
ELISA, WB
Description
Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions(By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | acyl-CoA synthetase short-chain family member 1 |
| Host | Rabbit |
| Reactivity | human,mouse,rat |
| Recommended Dilution | WB: 1:1000-1:10000; IP: 1:200-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 75 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9NUB1 |
| Gene ID | 84532 |
| Alias | ACAS2L,ACECS1,AceCS2L |
| Background | Antibody anti-ACSS1 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
ACSS1 is a mitochondrial enzyme that activates short-chain fatty acids, primarily acetate, by converting them into acetyl-CoA, which serves as a substrate for the tricarboxylic acid (TCA) cycle, lipid synthesis, and protein acetylation. It is expressed predominantly in tissues with high metabolic demand, such as the liver, heart, and skeletal muscle, where it facilitates energy production and metabolic flexibility. ACSS1 plays a pivotal role in maintaining energy homeostasis during fasting or ketogenic states by metabolizing acetate derived from dietary sources or fatty acid oxidation. Dysregulation of ACSS1 has been linked to metabolic disorders, such as obesity and diabetes, where impaired acetate metabolism affects energy balance and lipid biosynthesis. Its role in mitochondrial acetyl-CoA production underscores its importance in supporting cellular metabolism and adapting to changes in energy availability.
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Human ACSS1(Acyl-CoA synthetase short-chain family member 1) ELISA Kit
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anti- ACSS1 antibody
Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions(By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2).
Ver Producto