Recombinant Human ACSS1

Background

ACSS1 is a mitochondrial enzyme that activates short-chain fatty acids, primarily acetate, by converting them into acetyl-CoA, which serves as a substrate for the tricarboxylic acid (TCA) cycle, lipid synthesis, and protein acetylation. It is expressed predominantly in tissues with high metabolic demand, such as the liver, heart, and skeletal muscle, where it facilitates energy production and metabolic flexibility. ACSS1 plays a pivotal role in maintaining energy homeostasis during fasting or ketogenic states by metabolizing acetate derived from dietary sources or fatty acid oxidation. Dysregulation of ACSS1 has been linked to metabolic disorders, such as obesity and diabetes, where impaired acetate metabolism affects energy balance and lipid biosynthesis. Its role in mitochondrial acetyl-CoA production underscores its importance in supporting cellular metabolism and adapting to changes in energy availability.