ACOT7 antibody
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935106861
info@markelab.com
name
ACOT7 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00093
tested applications
ELISA, WB, IHC
Description
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A(CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May play an important physiological function in brain. May play a regulatory role by modulating the cellular levels of fatty acyl-CoA ligands for certain transcription factors as well as the substrates for fatty acid metabolizing enzymes, contributing to lipid homeostasis. Has broad specificity, active towards fatty acyl-CoAs with chain-lengths of C8-C18. Has a maximal activity toward palmitoyl-CoA.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | acyl-CoA thioesterase 7 (ACOT7) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:1000-1:5000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 40 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | O00154 |
| Gene ID | 11332 |
| Alias | ACT,ACH1,BACH,LACH,LACH1,hBACH,CTE-II |
| Background | Antibody anti-ACOT7 |
| Status | RUO |
| Note | Mol. Weight 40 kDa |
Descripción
ACOT7, also known as brain acyl-CoA hydrolase, is a cytosolic enzyme that hydrolyzes medium- and long-chain acyl-CoA esters, influencing lipid metabolism and cellular energy dynamics. It is highly expressed in the brain and testis, where it plays a role in modulating lipid signaling molecules, such as arachidonic acid and its derivatives, which are critical for neuronal function and inflammation. ACOT7 regulates the intracellular availability of free fatty acids and CoA, impacting processes like membrane synthesis, signaling, and energy production. In the nervous system, it is involved in neuroprotection and the regulation of synaptic function. Dysregulation of ACOT7 has been linked to neuroinflammatory disorders, such as multiple sclerosis, and metabolic diseases that involve disrupted fatty acid signaling. Its tissue-specific functions highlight its importance in maintaining both neuronal and systemic lipid homeostasis.
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