Acyl-CoA Thioesterase 7 (ACOT7) Antibody
357.5€ (100 µg)
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Name
Acyl-CoA Thioesterase 7 (ACOT7) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx037896
Tested Applications
ELISA, WB, IHC
Description
Rabbit Polyclonal against the ACOT7 protein.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Acyl-CoA Thioesterase 7 (ACOT7) Immunogen: A peptide corresponding to middle region of human ACOT7 protein. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 42 kDa |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NM_181864 |
| Alias | ACT,ACH1,BACH,LACH,LACH1,hBACH,CTE-II |
| Background | Antibody anti-ACOT7 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ACOT7, also known as brain acyl-CoA hydrolase, is a cytosolic enzyme that hydrolyzes medium- and long-chain acyl-CoA esters, influencing lipid metabolism and cellular energy dynamics. It is highly expressed in the brain and testis, where it plays a role in modulating lipid signaling molecules, such as arachidonic acid and its derivatives, which are critical for neuronal function and inflammation. ACOT7 regulates the intracellular availability of free fatty acids and CoA, impacting processes like membrane synthesis, signaling, and energy production. In the nervous system, it is involved in neuroprotection and the regulation of synaptic function. Dysregulation of ACOT7 has been linked to neuroinflammatory disorders, such as multiple sclerosis, and metabolic diseases that involve disrupted fatty acid signaling. Its tissue-specific functions highlight its importance in maintaining both neuronal and systemic lipid homeostasis.
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