anti- ABCE1 antibody

Name: anti- ABCE1 antibody
Brand: FineTest
SKU: FNab00039
Availability: OnlineOnly

Este producto es parte de ABCE1 - ATP Binding Cassette Transporter E

Pida mas información

935106861

info@markelab.com

Precio

Precio a consultar

Antibody anti-ABCE1

proveedor

FineTest

reference

FNab00039

Tested Applications

ELISA, WB

reactivity

human,mouse

status

RUO

clonality

polyclonal

Descripción

Antagonizes the binding of 2-5A(5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly.

Background

ABCE1, also known as the ATP-binding cassette protein E1 or RNase L inhibitor (RLI), is a unique member of the ATP-binding cassette (ABC) transporter superfamily. Unlike most ABC transporters, which are involved in the translocation of various substrates across membranes, ABCE1 primarily functions in the regulation of RNA processing and translation. It is highly conserved across different species, highlighting its fundamental biological importance.ABCE1 works by inhibiting the activity of ribonuclease L, thereby opposing the antiviral properties of ribonuclease L and enabling the virus to synthesize viral proteins. Additionally, ABCE1 has been implicated in influencing tumor cell proliferation

Características del producto

clonality

polyclonal

reactivity

human,mouse

immunogen target

ATP-binding cassette, sub-family E(OABP), member 1

host

Rabbit

isotype

IgG

conjugation

Unconjugated

form

liquid

tested applications

ELISA, WB

observerd MW

67 kDa

purity

≥95% as determined by SDS-PAGE

purification

Immunogen affinity purified

recommended dilution

WB: 1:500-1:2000

size 1

100µg

storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

or code

ABCE1

alias

ABC38,OABP,RLI,RLI1,RNASEL1

uniprot id

https://www.uniprot.org/uniprotkb/P61221

gene id

https://www.ncbi.nlm.nih.gov/gene/6059

note

This product is for research use only.

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