ABCB9 antibody
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935106861
info@markelab.com
name
ABCB9 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00034
tested applications
ELISA, WB, IF
Description
ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Favors positively charged, aromatic or hydrophobic residues in the N-and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ATP-binding cassette, sub-family B(MDR/TAP), member 9 (ABCB9) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:200-1:2000; IF: 1:10-1:100 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 84 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9NP78 |
| Gene ID | 23457 |
| Alias | EST122234,TAPL |
| Background | Antibody anti-ABCB9 |
| Status | RUO |
| Note | Mol. Weight 84 kDa |
Descripción
ABCB9, also known as TAPL (Transporter Associated with Antigen Processing-Like), is an ATP-binding cassette transporter localized to lysosomes and late endosomes. It plays a role in the transport of peptides into lysosomal compartments, contributing to processes such as antigen presentation and lysosomal proteostasis. ABCB9 contains two nucleotide-binding domains and transmembrane regions that mediate ATP-dependent peptide transport. It is expressed in various tissues, with higher levels in immune-related cells, where it supports lysosomal function and immune responses. Although its precise physiological substrates and roles remain under investigation, ABCB9’s involvement in lysosomal function underscores its importance in cellular homeostasis, immune regulation, and protein degradation pathways.
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