ATP Binding Cassette Transporter B9 (ABCB9) Antibody

Background

ABCB9, also known as TAPL (Transporter Associated with Antigen Processing-Like), is an ATP-binding cassette transporter localized to lysosomes and late endosomes. It plays a role in the transport of peptides into lysosomal compartments, contributing to processes such as antigen presentation and lysosomal proteostasis. ABCB9 contains two nucleotide-binding domains and transmembrane regions that mediate ATP-dependent peptide transport. It is expressed in various tissues, with higher levels in immune-related cells, where it supports lysosomal function and immune responses. Although its precise physiological substrates and roles remain under investigation, ABCB9’s involvement in lysosomal function underscores its importance in cellular homeostasis, immune regulation, and protein degradation pathways.