Annexin A3 (ANXA3) Antibody
169€ (20 µg)
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name
Annexin A3 (ANXA3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx333947
tested applications
ELISA, IHC
Description
ANXA3 Antibody is a Rabbit Polyclonal against ANXA3.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Annexin A3 (ANXA3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/10 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P12429 |
| Gene ID | 306 |
| Alias | ANXA3,ANX3,Annexin-3,Lipocortin III |
| Background | Antibody anti-ANXA3 |
| Status | RUO |
Descripción
ANXA3 is a calcium- and phospholipid-binding protein that regulates membrane trafficking, signal transduction, and inflammatory responses. It is expressed in various tissues, including immune and endothelial cells, and plays a role in angiogenesis and immune cell function. ANXA3 regulates phospholipase A2 (PLA2) activity, influencing arachidonic acid metabolism and eicosanoid production during inflammation. Dysregulation of ANXA3 has been associated with drug resistance in cancer cells, particularly in ovarian and colorectal cancers, where it enhances tumor cell survival and chemoresistance. Its involvement in immune responses and tumor progression underscores its significance as a potential biomarker and therapeutic target.
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Annexin A3(Anxa3), also named as lipocortin3, placental anticoagulant protein3(PAP-III), belongs to annexin family. Annexins are calcium-dependent phospholipids-binding high-abundant intracellular proteins. ANXA3 has been reported to play crucial roles in a diverse range of molecular and cellular processes, including ion channel regulation, anticoagulation, anti-inflammation, vesicle traffick-ing, signal transduction, cell migration, and cell proliferation. It also exhibits important roles in cancer progression, metastasis, and drug resistance.
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