Aminoadipate Aminotransferase (AADAT) Antibody (HRP)
169€ (20 µg)
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Name
Aminoadipate Aminotransferase (AADAT) Antibody (HRP)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx309664
Tested Applications
ELISA
Description
AADAT Antibody (HRP) is a Rabbit Polyclonal against AADAT conjugated to HRP.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Aminoadipate Aminotransferase (AADAT) Immunogen: Recombinant human Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial protein (30-425AA). |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | HRP |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8N5Z0 |
| Gene ID | 51166 |
| NCBI Accession | NP_001273611.1, NM_001286682.1, NP_001273612.1, NM_001286683.1 |
| OMIM | 611754 |
| Alias | KAT2,KATII,KYAT2,Kynurenine Aminotransferase II |
| Background | Antibody anti-AADAT |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Aminoadipate aminotransferase (AADAT), also known as kynurenine aminotransferase II (KAT II), is a mitochondrial enzyme that catalyzes the transamination of kynurenine to kynurenic acid (KYNA), a neuroactive metabolite in the kynurenine pathway of tryptophan metabolism. KYNA acts as an antagonist of NMDA and alpha-7 nicotinic acetylcholine receptors, regulating excitotoxicity and neuroinflammation in the brain. AADAT is expressed in various tissues, with high activity in the brain, where it influences neurotransmission and neuroprotection. Dysregulation of AADAT or kynurenine pathway metabolites has been linked to neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and schizophrenia, as well as cancer and immune-related disorders.
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