Alpha-Protein Kinase 2 (ALPK2) Antibody
221€ (50 µg)
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935106861
info@markelab.com
name
Alpha-Protein Kinase 2 (ALPK2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx322999
tested applications
ELISA, IHC
Description
ALPK2 Antibody is a Rabbit Polyclonal against ALPK2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Alpha-Protein Kinase 2 (ALPK2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/40000, IHC: 1/100 - 1/300. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q86TB3 |
| Gene ID | 115701 |
| Alias | ALPK2,HAK |
| Background | Antibody anti-ALPK2 |
| Status | RUO |
Descripción
ALPK2 is a member of the alpha-protein kinase family, a group of atypical serine/threonine kinases that phosphorylate substrates in regions of alpha-helical structures. ALPK2 is primarily expressed in epithelial tissues, where it is involved in processes such as cellular signaling, proliferation, and stress responses. Recent studies indicate that ALPK2 plays a significant role in inflammation and tumorigenesis. Its upregulation has been observed in colorectal and gastric cancers, suggesting a link between ALPK2 and cancer progression through its ability to activate pro-inflammatory pathways, such as NF-κB signaling. By promoting cytokine production and immune cell recruitment, ALPK2 may facilitate chronic inflammation, which contributes to tumor microenvironment remodeling. Additionally, ALPK2 is believed to influence epithelial-mesenchymal transition (EMT), a critical step in cancer metastasis. Dysregulation of ALPK2 may also impact cellular homeostasis, making it a potential biomarker for gastrointestinal cancers and inflammatory diseases.
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