Alpha-Protein Kinase 2 (ALPK2) Antibody
357.5€ (100 µg)
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935106861
info@markelab.com
name
Alpha-Protein Kinase 2 (ALPK2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx037584
tested applications
ELISA, WB
Description
Rabbit Polyclonal against the ALPK2 protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Alpha-Protein Kinase 2 (ALPK2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NM_052947.3 |
| Alias | ALPK2,HAK |
| Background | Antibody anti-ALPK2 |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
ALPK2 is a member of the alpha-protein kinase family, a group of atypical serine/threonine kinases that phosphorylate substrates in regions of alpha-helical structures. ALPK2 is primarily expressed in epithelial tissues, where it is involved in processes such as cellular signaling, proliferation, and stress responses. Recent studies indicate that ALPK2 plays a significant role in inflammation and tumorigenesis. Its upregulation has been observed in colorectal and gastric cancers, suggesting a link between ALPK2 and cancer progression through its ability to activate pro-inflammatory pathways, such as NF-κB signaling. By promoting cytokine production and immune cell recruitment, ALPK2 may facilitate chronic inflammation, which contributes to tumor microenvironment remodeling. Additionally, ALPK2 is believed to influence epithelial-mesenchymal transition (EMT), a critical step in cancer metastasis. Dysregulation of ALPK2 may also impact cellular homeostasis, making it a potential biomarker for gastrointestinal cancers and inflammatory diseases.
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