Alpha-Protein Kinase 2 (ALPK2) Antibody
52€ (10 µg)
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935106861
info@markelab.com
name
Alpha-Protein Kinase 2 (ALPK2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx013677
tested applications
ELISA, IHC
Description
Rabbit polyclonal antibody against ALPK2 protein. Immunogen region is Internal.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Alpha-Protein Kinase 2 (ALPK2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/50 - 1/100, ELISA: 1/40000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q86TB3 |
| Alias | ALPK2,HAK |
| Background | Antibody anti-ALPK2 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
ALPK2 is a member of the alpha-protein kinase family, a group of atypical serine/threonine kinases that phosphorylate substrates in regions of alpha-helical structures. ALPK2 is primarily expressed in epithelial tissues, where it is involved in processes such as cellular signaling, proliferation, and stress responses. Recent studies indicate that ALPK2 plays a significant role in inflammation and tumorigenesis. Its upregulation has been observed in colorectal and gastric cancers, suggesting a link between ALPK2 and cancer progression through its ability to activate pro-inflammatory pathways, such as NF-κB signaling. By promoting cytokine production and immune cell recruitment, ALPK2 may facilitate chronic inflammation, which contributes to tumor microenvironment remodeling. Additionally, ALPK2 is believed to influence epithelial-mesenchymal transition (EMT), a critical step in cancer metastasis. Dysregulation of ALPK2 may also impact cellular homeostasis, making it a potential biomarker for gastrointestinal cancers and inflammatory diseases.
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