Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 6 (ALKBH6) Antibody
195€ (20 µl)
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935106861
info@markelab.com
name
Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 6 (ALKBH6) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx135923
tested applications
ELISA, WB
Description
ALKBH6 Antibody is a Rabbit Polyclonal against ALKBH6.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 6 (ALKBH6) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q3KRA9 |
| Gene ID | 84964 |
| NCBI Accession | NP_116267.3 |
| Alias | ALKBH6,ABH6 |
| Background | Antibody anti-ALKBH6 |
| Status | RUO |
| Note | Concentration: > 0.2 mg/ml - |
Descripción
ALKBH6 is an α-KG- and Fe(II)-dependent dioxygenase whose precise biochemical and functional roles remain less defined compared to other ALKB family members. Preliminary evidence suggests that ALKBH6 may play a role in DNA and RNA repair, particularly in counteracting methylation damage caused by environmental alkylating agents. It is expressed in multiple tissues, including the liver, kidneys, and brain, where it is thought to contribute to cellular responses to genotoxic and oxidative stress. ALKBH6 may also participate in regulating cellular metabolism by linking α-KG availability to nucleic acid repair pathways. Its dysregulation has been associated with cellular stress and metabolic imbalances, suggesting a broader role in maintaining genomic integrity and energy homeostasis. Further studies are ongoing to elucidate its specific substrates and functional importance in health and disease.
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