Allograft Inflammatory Factor 1 (AIF1) Antibody
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Description
Allograft Inflammatory Factor 1 (AIF1) (Isoform 1 and 3) Antibody is a Goat Polyclonal antibody against Mouse Allograft Inflammatory Factor 1 (AIF1).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Allograft Inflammatory Factor 1 (AIF1) |
| Host | Goat |
| Reactivity | Mouse |
| Recommended Dilution | P-ELISA: 1/128000, WB: 0.3-1 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 1-3 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O70200 |
| Gene ID | 11629 |
| NCBI Accession | NP_116573.1, NP_001614.3 |
| Alias | AIF-1,IBA1,IRT-1,IRT1 |
| Background | Antibody anti-AIF1 |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
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anti- AIF1 antibody
AIF1, also named as G1, IBA1 or daintain/AIF-1, is a 143 amino acid cytoplasmic, inflammation response scaffold protein. It is constitutively expressed in monocytes and macrophages and is known to be involved in macrophage activation. It is a marker of activated macrophage. Despite a lack of detailed knowledge on the in vivo physiological functions of AIF-1, there is growing evidence that shows its aberrant expression contributes to the pathogenesis of many autoimmune diseases, including rheumatoid arthritis. (20944424). AIF1 is an actin-binding protein that enhances membrane ruffling and RAC activation. It enhances lymphocyte migration and the actin-bundling activity of LCP1. AIF1 plays a role in RAC signaling and in phagocytosis and a role in vascular inflammation. AIF1 promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. It is also as a microglial cell marker.
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