Allograft Inflammatory Factor 1 (AIF1) Antibody
357.5€ (100 µg)
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Name
Allograft Inflammatory Factor 1 (AIF1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx037687
Tested Applications
ELISA, WB
Description
Rabbit Polyclonal against the AIF1 protein.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Allograft Inflammatory Factor 1 (AIF1) Immunogen: A peptide corresponding to C-terminal region of human AIF1 protein. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 18 kDa |
| Purification | Purified by Protein A/G column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB |
| Buffer | Prior to lyophilization: 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P55008 |
| Gene ID | 199 |
| OMIM | 601833 |
| Alias | AIF-1,IBA1,IRT-1,IRT1 |
| Background | Antibody anti-AIF1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
AIF1 is an inflammation-responsive protein primarily expressed in macrophages, microglia, and other immune cells. It plays a critical role in immune regulation, particularly in modulating inflammatory responses, cell migration, and phagocytosis. Structurally, AIF1 contains EF-hand calcium-binding motifs, enabling it to respond to changes in intracellular calcium levels, which are key to immune cell activation and signaling. AIF1 is upregulated during inflammatory diseases such as autoimmune disorders, transplant rejection, and atherosclerosis, where it contributes to immune cell recruitment and tissue remodeling. It is also involved in promoting macrophage activation and migration to sites of injury or infection. Dysregulated AIF1 expression is associated with chronic inflammation, cancer progression, and neuroinflammatory diseases like multiple sclerosis, making it a potential biomarker and therapeutic target for inflammatory and immune-related disorders.
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