Allograft Inflammatory Factor 1 (AIF1) Antibody
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Description
AIF1 Antibody is a Rabbit Polyclonal antibody against AIF1. This gene is induced by cytokines and interferon. Its protein product is thought to be involved in negative regulation of growth of vascular smooth muscle cells, which contributes to the anti-inflammatory response to vessel wall trauma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008].
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Allograft Inflammatory Factor 1 (AIF1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/1000 - 1/5000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P55008 |
| Gene ID | 199 |
| NCBI Accession | NP_001614.3 |
| OMIM | 601833 |
| Alias | AIF-1,IBA1,IRT-1,IRT1 |
| Background | Antibody anti-AIF1 |
| Status | RUO |
| Note | Concentration: > 0.2 mg/ml - |
Descripción
AIF1 is an inflammation-responsive protein primarily expressed in macrophages, microglia, and other immune cells. It plays a critical role in immune regulation, particularly in modulating inflammatory responses, cell migration, and phagocytosis. Structurally, AIF1 contains EF-hand calcium-binding motifs, enabling it to respond to changes in intracellular calcium levels, which are key to immune cell activation and signaling. AIF1 is upregulated during inflammatory diseases such as autoimmune disorders, transplant rejection, and atherosclerosis, where it contributes to immune cell recruitment and tissue remodeling. It is also involved in promoting macrophage activation and migration to sites of injury or infection. Dysregulated AIF1 expression is associated with chronic inflammation, cancer progression, and neuroinflammatory diseases like multiple sclerosis, making it a potential biomarker and therapeutic target for inflammatory and immune-related disorders.
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AIF1, also named as G1, IBA1 or daintain/AIF-1, is a 143 amino acid cytoplasmic, inflammation response scaffold protein. It is constitutively expressed in monocytes and macrophages and is known to be involved in macrophage activation. It is a marker of activated macrophage. Despite a lack of detailed knowledge on the in vivo physiological functions of AIF-1, there is growing evidence that shows its aberrant expression contributes to the pathogenesis of many autoimmune diseases, including rheumatoid arthritis. (20944424). AIF1 is an actin-binding protein that enhances membrane ruffling and RAC activation. It enhances lymphocyte migration and the actin-bundling activity of LCP1. AIF1 plays a role in RAC signaling and in phagocytosis and a role in vascular inflammation. AIF1 promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. It is also as a microglial cell marker.
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