Aladin (AAAS) Antibody
221€ (50 µg)
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Name
Aladin (AAAS) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx330148
Tested Applications
ELISA, WB
Description
AAAS Antibody is a Rabbit Polyclonal against AAAS.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Aladin (AAAS) Immunogen: Synthesized peptide derived from the C-terminal region of human Aladin. |
| Host | Rabbit |
| Reactivity | Human, Rat |
| Recommended Dilution | ELISA: 1/40000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9NRG9 |
| Gene ID | 8086 |
| Alias | AAA,AAASb,GL003,ALADIN,ADRACALA,ADRACALIN |
| Background | Antibody anti-AAAS |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Aladin, also known as adracalin, is a nucleoporin that in humans is encoded by the AAAS gene, located on chromosome 12q13.Aladin is primarily expressed in the adrenal gland, brain, and peripheral nervous system. Mutations in the AAAS gene result in dysfunction or loss of function of the Aladin protein. It iwas linked to a triple A syndrome ( also known as Allgrove Syndrome) which occurs when the gene is mutated. The AAAs gene product is a protein of 60 Kd. Aladin is a component of the nuclear pore complex, to which it is attached by nucleoporin NDC1. Mutant aladin causes selective failure of nuclear protein import and hypersensitivity to oxidative stress
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