Aladin (AAAS) Antibody
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935106861
info@markelab.com
Precio
195€ (20 µl)
Antibody anti-AAAS
proveedor
Abbexareference
abx004920Tested Applications
ELISA, WBreactivity
Humanstatus
RUOclonality
PolyclonalDescripción
AAAS Antibody is a Rabbit Polyclonal antibody against AAAS. The protein encoded by this gene is a member of the WD-repeat family of regulatory proteins and may be involved in normal development of the peripheral and central nervous system. The encoded protein is part of the nuclear pore complex and is anchored there by NDC1. Defects in this gene are a cause of achalasia-addisonianism-alacrima syndrome (AAAS), also called triple-A syndrome or Allgrove syndrome. Two transcript variants encoding different isoforms have been found for this gene.
Background
Aladin, also known as adracalin, is a nucleoporin that in humans is encoded by the AAAS gene, located on chromosome 12q13.Aladin is primarily expressed in the adrenal gland, brain, and peripheral nervous system. Mutations in the AAAS gene result in dysfunction or loss of function of the Aladin protein. It iwas linked to a triple A syndrome ( also known as Allgrove Syndrome) which occurs when the gene is mutated. The AAAs gene product is a protein of 60 Kd. Aladin is a component of the nuclear pore complex, to which it is attached by nucleoporin NDC1. Mutant aladin causes selective failure of nuclear protein import and hypersensitivity to oxidative stress
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human
immunogen target
Aladin (AAAS)
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB
purification
Purified by affinity chromatography.
recommended dilution
ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
buffer
PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
size 1
20 µl
size 2
100 µl
size 3
2 × 100 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
AAAS
dry ice
No
availability
Shipped within 5-10 working days.
alias
AAA,AAASb,GL003,ALADIN,ADRACALA,ADRACALIN
uniprot id
NCBI accession
NP_056480.1
note
Concentration: > 0.2 mg/ml -
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Abbexareference
abx004920Tested Applications
ELISA, WBreactivity
Humanstatus
RUOclonality
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