AKAP14 Cell ELISA Kit
513.5€ (96 tests)
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name
AKAP14 Cell ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx595897
tested applications
ELISA
Description
AKAP14 Cell ELISA Kit is a cell-based ELISA Kit. Cells to be assayed should be seeded onto a clear flat bottom 96 well plate, using poly-L-lysine for non-adherent cells. Cells should be grown to 75-90% confluence and treated prior to carrying out the ELISA.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | AKAP14 |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Tested Applications | ELISA |
| Availability | Shipped within 1-2 weeks. The validity for this kit is at least 6 months |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q86UN6 |
| Gene ID | 158798 |
| OMIM | 300462 |
| Alias | AKAP28,PRKA14 |
| Background | Elisa kits for AKAP14 |
| Status | RUO |
| Note | Validity: 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
AKAP14 is a testis-specific anchoring protein that plays a pivotal role in sperm function by organizing PKA signaling pathways essential for spermatogenesis and sperm motility. AKAP14 localizes to the sperm flagellum, where it anchors PKA and other signaling enzymes, coordinating cAMP-dependent processes that regulate flagellar beat and capacitation. It interacts with proteins in the axoneme structure, ensuring proper assembly and maintenance of sperm tail components necessary for motility. Loss or mutations in AKAP14 disrupt PKA signaling, leading to reduced sperm motility and infertility. AKAP14 also facilitates ATP generation by organizing signaling complexes near mitochondria in the sperm midpiece, ensuring energy supply for flagellar movement. Studies suggest that AKAP14's role in cytoskeletal anchoring makes it a critical factor in maintaining sperm structure and function, linking it to male fertility and reproductive success.
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