A-Kinase Anchor Protein 14 (AKAP14) Antibody
52€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
A-Kinase Anchor Protein 14 (AKAP14) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx119565
tested applications
WB, IF/ICC
Description
AKAP14 Antibody is a Rabbit Polyclonal antibody against AKAP14.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | A-Kinase Anchor Protein 14 (AKAP14) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | WB, IF/ICC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q86UN6 |
| Alias | AKAP28,PRKA14 |
| Background | Antibody anti-AKAP14 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
AKAP14 is a testis-specific anchoring protein that plays a pivotal role in sperm function by organizing PKA signaling pathways essential for spermatogenesis and sperm motility. AKAP14 localizes to the sperm flagellum, where it anchors PKA and other signaling enzymes, coordinating cAMP-dependent processes that regulate flagellar beat and capacitation. It interacts with proteins in the axoneme structure, ensuring proper assembly and maintenance of sperm tail components necessary for motility. Loss or mutations in AKAP14 disrupt PKA signaling, leading to reduced sperm motility and infertility. AKAP14 also facilitates ATP generation by organizing signaling complexes near mitochondria in the sperm midpiece, ensuring energy supply for flagellar movement. Studies suggest that AKAP14's role in cytoskeletal anchoring makes it a critical factor in maintaining sperm structure and function, linking it to male fertility and reproductive success.
Related Products
AKAP14 antibody
Binds to type II regulatory subunits of protein kinase A and anchors/targets them.
Ver Producto
A-Kinase Anchor Protein 14 (AKAP14) Antibody
AKAP14 Antibody is a Rabbit Polyclonal antibody against AKAP14.
Ver Producto
A-Kinase Anchor Protein 14 (AKAP14) Antibody
AKAP14 Antibody is a Rabbit Polyclonal against AKAP14.
Ver Producto