A-Kinase Anchor Protein 14 (AKAP14) Antibody
377€ (100 µg)
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Name
A-Kinase Anchor Protein 14 (AKAP14) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx230253
Tested Applications
ELISA, WB, IHC
Description
AKAP14 Antibody is a Rabbit Polyclonal against AKAP14.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: A-Kinase Anchor Protein 14 (AKAP14) Immunogen: A kinase (PRKA) anchor protein 14 |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: 2 mg/ml |
| Recommended Dilution | WB: 1/200 - 1/2000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 28 kDa |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q86UN6 |
| Gene ID | 158798 |
| OMIM | 300462 |
| Alias | AKAP28,PRKA14 |
| Background | Antibody anti-AKAP14 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
AKAP14 is a testis-specific anchoring protein that plays a pivotal role in sperm function by organizing PKA signaling pathways essential for spermatogenesis and sperm motility. AKAP14 localizes to the sperm flagellum, where it anchors PKA and other signaling enzymes, coordinating cAMP-dependent processes that regulate flagellar beat and capacitation. It interacts with proteins in the axoneme structure, ensuring proper assembly and maintenance of sperm tail components necessary for motility. Loss or mutations in AKAP14 disrupt PKA signaling, leading to reduced sperm motility and infertility. AKAP14 also facilitates ATP generation by organizing signaling complexes near mitochondria in the sperm midpiece, ensuring energy supply for flagellar movement. Studies suggest that AKAP14's role in cytoskeletal anchoring makes it a critical factor in maintaining sperm structure and function, linking it to male fertility and reproductive success.
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