AKAP1 Cell ELISA Kit
513.5€ (96 tests)
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name
AKAP1 Cell ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx595922
tested applications
ELISA
Description
AKAP1 Cell ELISA Kit is a cell-based ELISA Kit. Cells to be assayed should be seeded onto a clear flat bottom 96 well plate, using poly-L-lysine for non-adherent cells. Cells should be grown to 75-90% confluence and treated prior to carrying out the ELISA.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | AKAP1 |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Tested Applications | ELISA |
| Availability | Shipped within 1-2 weeks. The validity for this kit is at least 6 months |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q92667 |
| Gene ID | 8165 |
| OMIM | 602449 |
| Alias | AKAP,AKAP121,AKAP149,AKAP84,D-AKAP1 |
| Background | Elisa kits for AKAP1 |
| Status | RUO |
| Note | Validity: 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
AKAP1 is a mitochondrial scaffold protein that anchors Protein Kinase A (PKA) and other signaling molecules to the outer mitochondrial membrane, regulating mitochondrial dynamics, energy production, and apoptosis. AKAP1 modulates mitochondrial membrane potential by organizing signaling complexes involving PKA, phosphatases, and other enzymes. It plays a significant role in cardiomyocyte survival, as it enhances mitochondrial respiration under stress by promoting ATP synthesis. AKAP1 is also involved in the regulation of mitochondrial fission and fusion through interactions with Drp1 and MFN2, thereby maintaining mitochondrial homeostasis. Loss of AKAP1 disrupts mitochondrial function and increases susceptibility to oxidative stress, contributing to neurodegeneration and heart failure. AKAP1 also regulates reactive oxygen species (ROS) production, influencing cellular aging and survival signaling pathways like AMPK. Recent studies have linked AKAP1 downregulation with metabolic disorders and impaired endothelial function, highlighting its role in vascular biology.
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