Adhesion G Protein-Coupled Receptor E3 (ADGRE3) Antibody

Background

ADGRE3, also known as EMR3, is a member of the adhesion GPCR family expressed mainly in myeloid and granulocytic cells. It is believed to contribute to immune regulation and cellular communication in the innate immune system, although its precise biological functions remain less well-defined compared to ADGRE1 and ADGRE2. ADGRE3 contains extracellular EGF-like domains, characteristic of this receptor family, which mediate interactions with the extracellular environment and other immune cells. It is thought to play a role in modulating inflammatory responses and potentially in tumor-associated immune processes. Dysregulation of ADGRE3 has been implicated in certain cancers and inflammatory conditions, suggesting its involvement in immune cell signaling and tissue remodeling.