Adhesion G Protein-Coupled Receptor D1 (ADGRD1) Antibody

Background

ADGRD1, also known as GPR133, is a member of the adhesion G protein-coupled receptor (GPCR) family, primarily involved in regulating cell signaling and adhesion. It is characterized by a large extracellular domain with a GPCR autoproteolysis-inducing (GAIN) domain, enabling receptor cleavage into an extracellular and a transmembrane subunit. ADGRD1 is highly expressed in the brain, particularly in neural stem cells, and plays a critical role in neurogenesis, neuronal migration, and maintaining blood-brain barrier integrity. It is also found in certain immune and vascular cell populations. The receptor contributes to cyclic AMP (cAMP) signaling pathways, influencing cellular growth and differentiation. Dysregulation of ADGRD1 has been associated with glioblastoma progression and altered tumor microenvironment signaling, making it a potential target for therapeutic interventions.