Adhesion G Protein-Coupled Receptor D1 (ADGRD1) Antibody
221€ (50 µg)
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935106861
info@markelab.com
name
Adhesion G Protein-Coupled Receptor D1 (ADGRD1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx325062
tested applications
ELISA, WB, IF/ICC
Description
GPR133 Antibody is a Rabbit Polyclonal against GPR133.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Adhesion G Protein-Coupled Receptor D1 (ADGRD1) |
| Host | Rabbit |
| Reactivity | Human, Monkey |
| Recommended Dilution | ELISA: 1/5000, WB: 1/500 - 1/2000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q6QNK2 |
| Gene ID | 283383 |
| Alias | ADGRD1,GPR133, PGR25,G protein-coupled receptor 133 |
| Background | Antibody anti-ADGRD1 |
| Status | RUO |
Descripción
ADGRD1, also known as GPR133, is a member of the adhesion G protein-coupled receptor (GPCR) family, primarily involved in regulating cell signaling and adhesion. It is characterized by a large extracellular domain with a GPCR autoproteolysis-inducing (GAIN) domain, enabling receptor cleavage into an extracellular and a transmembrane subunit. ADGRD1 is highly expressed in the brain, particularly in neural stem cells, and plays a critical role in neurogenesis, neuronal migration, and maintaining blood-brain barrier integrity. It is also found in certain immune and vascular cell populations. The receptor contributes to cyclic AMP (cAMP) signaling pathways, influencing cellular growth and differentiation. Dysregulation of ADGRD1 has been associated with glioblastoma progression and altered tumor microenvironment signaling, making it a potential target for therapeutic interventions.
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