Acidic Leucine-Rich Nuclear Phosphoprotein 32 Family Member C (ANP32C) Antibody

Name: Acidic Leucine-Rich Nuclear Phosphoprotein 32 Family Member C (ANP32C) Antibody
Brand: Abbexa
SKU: abx029467
Price: 281.25 EUR
Availability: OnlineOnly

Este producto es parte de ANP32 - Acidic leucine-rich nuclear phosphoprotein 32 family

Pida mas información

935106861

info@markelab.com

Precio

281.25€ (80 µl)

Antibody anti-ANP32CP

proveedor

Abbexa

reference

abx029467

Tested Applications

ELISA, WB

reactivity

Human

status

RUO

clonality

Polyclonal

Descripción

Phosphoprotein 32 (PP32) is a tumor suppressor that can inhibit several types of cancers, including prostate and breast cancers. The protein encoded by this gene is one of at least two proteins that are similar in amino acid sequence to PP32 and are part of the same acidic nuclear phosphoprotein gene family. However, unlike PP32, the encoded protein is tumorigenic. The tumor suppressor function of PP32 has been localized to a 25 amino acid region that is divergent between PP32 and the protein encoded by this gene. This gene does not contain introns. [provided by RefSeq].

Background

ANP32CP, also known as ANP32E, is a member of the ANP32 family that plays a significant role in histone dynamics and chromatin remodeling. ANP32CP regulates the exchange and deposition of histone H2A.Z, a histone variant that influences transcriptional regulation, DNA repair, and chromatin structure. By modulating H2A.Z localization, ANP32CP is involved in regulating gene expression, DNA damage response, and genomic stability. Its activity is crucial for cellular differentiation, proliferation, and stress adaptation. Dysregulation of ANP32CP has been associated with cancer, where altered histone dynamics promote transcriptional changes driving tumor progression. Its role in histone regulation highlights its significance in maintaining chromatin integrity and cellular homeostasis.

Características del producto

clonality

Polyclonal

reactivity

Human

immunogen target

Acidic Leucine-Rich Nuclear Phosphoprotein 32 Family Member C (ANP32C)

host

Rabbit

conjugation

Unconjugated

form

Liquid

tested applications

ELISA, WB

purification

Purified through a protein A column, followed by peptide affinity purification.

buffer

PBS containing 0.09% sodium azide.

size 1

80 µl

size 2

400 µl

storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

or code

ANP32CP

dry ice

availability

Shipped within 5-10 working days.

alias

ANP32C,PP32R1

uniprot id

https://www.uniprot.org/uniprotkb/O43423

note

This product is for research use only.

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