Acidic Leucine-Rich Nuclear Phosphoprotein 32 Family Member C (ANP32C) Antibody

Background

ANP32CP, also known as ANP32E, is a member of the ANP32 family that plays a significant role in histone dynamics and chromatin remodeling. ANP32CP regulates the exchange and deposition of histone H2A.Z, a histone variant that influences transcriptional regulation, DNA repair, and chromatin structure. By modulating H2A.Z localization, ANP32CP is involved in regulating gene expression, DNA damage response, and genomic stability. Its activity is crucial for cellular differentiation, proliferation, and stress adaptation. Dysregulation of ANP32CP has been associated with cancer, where altered histone dynamics promote transcriptional changes driving tumor progression. Its role in histone regulation highlights its significance in maintaining chromatin integrity and cellular homeostasis.