Acidic Leucine-Rich Nuclear Phosphoprotein 32 Family Member C (ANP32C) Antibody
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Description
Rabbit polyclonal antibody against ANP32C protein. Immunogen region is Internal.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Acidic Leucine-Rich Nuclear Phosphoprotein 32 Family Member C (ANP32C) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/3000, ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O43423 |
| Alias | ANP32C,PP32R1 |
| Background | Antibody anti-ANP32CP |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
ANP32CP, also known as ANP32E, is a member of the ANP32 family that plays a significant role in histone dynamics and chromatin remodeling. ANP32CP regulates the exchange and deposition of histone H2A.Z, a histone variant that influences transcriptional regulation, DNA repair, and chromatin structure. By modulating H2A.Z localization, ANP32CP is involved in regulating gene expression, DNA damage response, and genomic stability. Its activity is crucial for cellular differentiation, proliferation, and stress adaptation. Dysregulation of ANP32CP has been associated with cancer, where altered histone dynamics promote transcriptional changes driving tumor progression. Its role in histone regulation highlights its significance in maintaining chromatin integrity and cellular homeostasis.
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