Acetyl Coenzyme A Acetyltransferase 1 (ACAT1) Antibody (Biotin)
416€ (200 µl)
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935106861
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name
Acetyl Coenzyme A Acetyltransferase 1 (ACAT1) Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx431049
tested applications
P-ELISA, WB
Description
ACAT1 Antibody is a Goat Polyclonal antibody against ACAT1 (
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Acetyl Coenzyme A Acetyltransferase 1 (ACAT1) |
| Host | Goat |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | P-ELISA: 1/4000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 1-3 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 38, 110446, 25014 |
| NCBI Accession | NP_000010.1 |
| Alias | ACAT,MAT,T2,THIL,Acetoacetyl-CoA thiolase |
| Background | Antibody anti-ACAT1 |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
ACAT1, also known as mitochondrial acetoacetyl-CoA thiolase, is an enzyme localized in the mitochondria that catalyzes the reversible conversion of two molecules of acetyl-CoA into acetoacetyl-CoA, a critical step in ketone body synthesis and cholesterol metabolism. It is involved in energy production during periods of fasting or carbohydrate restriction by contributing to ketogenesis. ACAT1 also plays a role in the breakdown of branched-chain amino acids, linking it to amino acid metabolism. Dysregulation or mutations in the ACAT1 gene have been implicated in rare metabolic disorders such as beta-ketothiolase deficiency, which is characterized by the inability to properly metabolize ketogenic amino acids and fatty acids, leading to metabolic acidosis. Recent studies have also suggested a potential role for ACAT1 in cancer metabolism, where its activity is linked to metabolic reprogramming in tumor cells.
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