Acetyl Coenzyme A Acetyltransferase 1 (ACAT1) Antibody
364€ (100 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Acetyl Coenzyme A Acetyltransferase 1 (ACAT1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx230072
tested applications
ELISA, WB, IHC
Description
ACAT1 Antibody is a Rabbit Polyclonal against ACAT1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Acetyl Coenzyme A Acetyltransferase 1 (ACAT1) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P24752 |
| Alias | ACAT,MAT,T2,THIL,Acetoacetyl-CoA thiolase |
| Background | Antibody anti-ACAT1 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
ACAT1, also known as mitochondrial acetoacetyl-CoA thiolase, is an enzyme localized in the mitochondria that catalyzes the reversible conversion of two molecules of acetyl-CoA into acetoacetyl-CoA, a critical step in ketone body synthesis and cholesterol metabolism. It is involved in energy production during periods of fasting or carbohydrate restriction by contributing to ketogenesis. ACAT1 also plays a role in the breakdown of branched-chain amino acids, linking it to amino acid metabolism. Dysregulation or mutations in the ACAT1 gene have been implicated in rare metabolic disorders such as beta-ketothiolase deficiency, which is characterized by the inability to properly metabolize ketogenic amino acids and fatty acids, leading to metabolic acidosis. Recent studies have also suggested a potential role for ACAT1 in cancer metabolism, where its activity is linked to metabolic reprogramming in tumor cells.
Related Products
Human ACAT1 (Acetyl-CoA acetyltransferase, mitochondrial) ELISA Kit
Ver Producto
ACAT1 antibody
This gene encodes a mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. Defects in this gene are associated with 3-ketothiolase deficiency, an inborn error of isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone.
Ver Producto