A Kinase Anchor Protein 17A (AKAP17A) Antibody
169€ (20 µg)
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name
A Kinase Anchor Protein 17A (AKAP17A) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx301031
tested applications
ELISA, IF/ICC
Description
AKAP17A Antibody is a Rabbit Polyclonal against AKAP17A.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | A Kinase Anchor Protein 17A (AKAP17A) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q02040 |
| Gene ID | 8227 |
| NCBI Accession | NP_005079.2, NM_005088.2 |
| OMIM | 312095 |
| Alias | 721P,AKAP-17A,CCDC133 |
| Background | Antibody anti-AKAP17A |
| Status | RUO |
Descripción
AKAP17A, also known as S-AKAP84, is a mitochondrial scaffold protein that binds PKA and regulates mitochondrial function, including ATP production and apoptosis. AKAP17A primarily anchors PKA to the mitochondrial membrane, facilitating cAMP-dependent signaling pathways that control oxidative phosphorylation and energy homeostasis. It has a role in maintaining mitochondrial integrity during cellular stress by regulating apoptosis signaling, including interactions with pro- and anti-apoptotic proteins like Bcl-2 and caspases. AKAP17A is expressed in tissues with high energy demands, such as cardiac and skeletal muscle, where it enhances mitochondrial respiration. Dysregulation of AKAP17A impairs mitochondrial dynamics, contributing to metabolic disorders, neurodegeneration, and cardiovascular diseases. AKAP17A has also been shown to interact with mitochondrial DNA-binding proteins, influencing mitochondrial biogenesis and replication under stress conditions.
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