A Kinase Anchor Protein 17A (AKAP17A) Antibody
637€ (100 µl)
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Name
A Kinase Anchor Protein 17A (AKAP17A) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx115804
Tested Applications
ELISA, WB, IHC, IF/ICC
Description
Splicing Factor, Arginine/Serine-Rich 17A Antibody is a Rabbit Polyclonal antibody against Splicing Factor, Arginine/Serine-Rich 17A.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: A Kinase Anchor Protein 17A (AKAP17A) Immunogen: Human SFRS17A. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q02040 |
| Gene ID | 8227 |
| NCBI Accession | NP_005079.2, NM_005088.2 |
| OMIM | 312095 |
| Alias | 721P,AKAP-17A,CCDC133 |
| Background | Antibody anti-AKAP17A |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
AKAP17A, also known as S-AKAP84, is a mitochondrial scaffold protein that binds PKA and regulates mitochondrial function, including ATP production and apoptosis. AKAP17A primarily anchors PKA to the mitochondrial membrane, facilitating cAMP-dependent signaling pathways that control oxidative phosphorylation and energy homeostasis. It has a role in maintaining mitochondrial integrity during cellular stress by regulating apoptosis signaling, including interactions with pro- and anti-apoptotic proteins like Bcl-2 and caspases. AKAP17A is expressed in tissues with high energy demands, such as cardiac and skeletal muscle, where it enhances mitochondrial respiration. Dysregulation of AKAP17A impairs mitochondrial dynamics, contributing to metabolic disorders, neurodegeneration, and cardiovascular diseases. AKAP17A has also been shown to interact with mitochondrial DNA-binding proteins, influencing mitochondrial biogenesis and replication under stress conditions.
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