A Kinase Anchor Protein 17A (AKAP17A) Antibody

Background

AKAP17A, also known as S-AKAP84, is a mitochondrial scaffold protein that binds PKA and regulates mitochondrial function, including ATP production and apoptosis. AKAP17A primarily anchors PKA to the mitochondrial membrane, facilitating cAMP-dependent signaling pathways that control oxidative phosphorylation and energy homeostasis. It has a role in maintaining mitochondrial integrity during cellular stress by regulating apoptosis signaling, including interactions with pro- and anti-apoptotic proteins like Bcl-2 and caspases. AKAP17A is expressed in tissues with high energy demands, such as cardiac and skeletal muscle, where it enhances mitochondrial respiration. Dysregulation of AKAP17A impairs mitochondrial dynamics, contributing to metabolic disorders, neurodegeneration, and cardiovascular diseases. AKAP17A has also been shown to interact with mitochondrial DNA-binding proteins, influencing mitochondrial biogenesis and replication under stress conditions.