A Disintegrin And Metalloproteinase With Thrombospondin 19 (ADAMTS19) Antibody
292.5€ (80 µl)
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935106861
info@markelab.com
name
A Disintegrin And Metalloproteinase With Thrombospondin 19 (ADAMTS19) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx033402
tested applications
ELISA, WB
Description
ADAMTS19 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | A Disintegrin And Metalloproteinase With Thrombospondin 19 (ADAMTS19) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8TE59 |
| Alias | CVDP2,A Disintegrin And Metalloproteinase With Thrombospondin Motifs 19,CVDP2,ADAMTS-19,ADAM-TS19 |
| Background | Antibody anti-ADAMTS19 |
| Status | RUO |
Descripción
ADAMTS19, short for A Disintegrin And Metalloproteinase with Thrombospondin Motifs 19, is a member of the ADAMTS protein family. Like other members of the ADAMTS family, ADAMTS19 contains multiple domains, including a metalloproteinase domain responsible for its proteolytic activity, as well as thrombospondin type-1 (TSP-1) motifs. ADAMTS19 is expressed in various tissues and organs, including the brain, heart, lung, and skeletal muscle, suggesting its involvement in multiple physiological processes.The precise function of ADAMTS19 is not fully understood, but it is thought to be involved in ECM remodeling, cell adhesion, and tissue development. Studies have suggested potential roles for ADAMTS19 in heart development and function, as well as in skeletal muscle biology.Mutations or dysregulation of ADAMTS19 have been implicated in several diseases and disorders. For example, mutations in the ADAMTS19 gene have been linked to a rare genetic disorder known as geleophysic dysplasia. This condition is characterized by short stature, distinctive facial features, joint stiffness, and other skeletal abnormalities.
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