Family main features
ADAMTS19, short for A Disintegrin And Metalloproteinase with Thrombospondin Motifs 19, is a member of the ADAMTS protein family. Like other members of the ADAMTS family, ADAMTS19 contains multiple domains, including a metalloproteinase domain responsible for its proteolytic activity, as well as thrombospondin type-1 (TSP-1) motifs. ADAMTS19 is expressed in various tissues and organs, including the brain, heart, lung, and skeletal muscle, suggesting its involvement in multiple physiological processes.The precise function of ADAMTS19 is not fully understood, but it is thought to be involved in ECM remodeling, cell adhesion, and tissue development. Studies have suggested potential roles for ADAMTS19 in heart development and function, as well as in skeletal muscle biology.Mutations or dysregulation of ADAMTS19 have been implicated in several diseases and disorders. For example, mutations in the ADAMTS19 gene have been linked to a rare genetic disorder known as geleophysic dysplasia. This condition is characterized by short stature, distinctive facial features, joint stiffness, and other skeletal abnormalities. Additionally, alterations in ADAMTS19 expression have been observed in certain types of cancer, although the significance of these findings is still being investigated.
ADAMTS19 exhibits a complex multi-domain structure typical of ADAMTS family members:
ADAMTS19 is classified within the ADAMTS family, which includes several enzymes sharing similar structural domains. While there are no specific subtypes of ADAMTS19, it shares functional and structural characteristics with other members of the ADAMTS family.
ADAMTS19 is involved in several key biological processes:
ADAMTS19 interacts with several proteins and cellular components:
ADAMTS19 has significant clinical implications in various contexts:
ADAMTS19 is a crucial enzyme in the ADAMTS family, contributing to ECM remodeling, tissue development, and maintenance of various tissues. Its multi-domain structure, including the metalloprotease and TSP1 domains, enables it to interact with various ECM components and cellular receptors. ADAMTS19 plays essential roles in maintaining tissue integrity and influencing cardiovascular health and disease. Understanding its structure, functions, interactions, and clinical implications provides valuable insights into its roles in various physiological and pathological processes.
ADAM metallopeptidase with thrombospondin type 1 motif 19(ADAMTS19)
CVDP2,A Disintegrin And Metalloproteinase With Thrombospondin Motifs 19,CVDP2,ADAMTS-19,ADAM-TS19
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, ELISA Kits) relacionados con ADAMTS19 - ADAM metallopeptidase with thrombospondin type 1 motif 19
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Esta página contiene 7 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | ADAMTS19 | abx503221 | Human A disintegrin and metalloproteinase with thrombospondin motifs 19 (ADAMTS19) ELISA Kit | Human | Serum,Plasma,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q8TE59 | RUO | ||
Abbexa | ADAMTS19 | abx503222 | Mouse A disintegrin and metalloproteinase with thrombospondin motifs 19 (ADAMTS19) ELISA Kit | Mouse | Serum,Plasma,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | P59509 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | ADAMTS19 | abx128128 | A Disintegrin And Metalloproteinase With Thrombospondin 19 (ADAMTS19) Antibody | Human | Polyclonal | Rabbit | A Disintegrin And Metalloproteinase With Thrombospondin 19 (ADAMTS19) | Unconjugated | WB, IHC, IF/ICC | 287.5 | 100 µl | RUO | ||
Abbexa | ADAMTS19 | abx210615 | A Disintegrin And Metalloproteinase With Thrombospondin 19 (ADAMTS19) Antibody | Human | Polyclonal | Rabbit | A Disintegrin And Metalloproteinase With Thrombospondin 19 (ADAMTS19) | Unconjugated | ELISA, IHC | 250 | 50 µl | Q8TE59 | RUO | |
Abbexa | ADAMTS19 | abx033402 | A Disintegrin And Metalloproteinase With Thrombospondin 19 (ADAMTS19) Antibody | Human | Polyclonal | Rabbit | A Disintegrin And Metalloproteinase With Thrombospondin 19 (ADAMTS19) | Unconjugated | ELISA, WB | 281.25 | 80 µl | Q8TE59 | RUO | |
Abbexa | ADAMTS19 | abx325575 | A Disintegrin And Metalloproteinase With Thrombospondin 19 (ADAMTS19) Antibody | Human | Polyclonal | Rabbit | A Disintegrin And Metalloproteinase With Thrombospondin 19 (ADAMTS19) | Unconjugated | ELISA, WB | 187.5 | 50 µg | Q8TE59 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | ADAMTS19 | abx168203 | Human A Disintegrin And Metalloproteinase With Thrombospondin 19 (ADAMTS19) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | RUO |
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