5-Hydroxytryptamine Receptor 5A / 5-HT5A (HTR5A) Antibody
52€ (10 µg)
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935106861
info@markelab.com
name
5-Hydroxytryptamine Receptor 5A / 5-HT5A (HTR5A) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx013889
tested applications
ELISA, WB
Description
Rabbit polyclonal antibody against 5-HT-5A protein. Immunogen region is Internal.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | 5-Hydroxytryptamine Receptor 5A / 5-HT5A (HTR5A) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/3000, ELISA: 1/20000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P47898 |
| Alias | HTR5A,5-HT5A,5-HT5A receptor |
| Background | Antibody anti-HTR5A |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
HTR5A is a G protein-coupled serotonin receptor predominantly found in the central nervous system, where it modulates serotonin's effects on neuronal excitability and synaptic signaling. HTR5A is expressed in regions like the hippocampus, cortex, and hypothalamus, and it is involved in regulating functions such as learning, memory consolidation, and mood stabilization. The receptor couples to G proteins, inhibiting adenylate cyclase activity and thereby reducing intracellular cAMP levels. Studies have shown that HTR5A plays a role in mood regulation, with dysregulation linked to depression, schizophrenia, and other psychiatric disorders. Additionally, HTR5A modulates circadian rhythms and sleep patterns, suggesting its involvement in sleep regulation. Genetic variations in the HTR5A gene have been associated with altered serotonergic signaling, influencing individual susceptibility to mood disorders and response to serotonergic therapies. Although HTR5A remains less characterized compared to other serotonin receptors, it continues to be a target for developing treatments for neurological diseases, sleep disturbances, and affective disorders, highlighting its importance in serotonin-mediated signaling pathways.
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